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body {
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.footer-widgets-1,  .footer-widgets-2, .footer-widgets-3, .footer-widgets-4, .footer-widgets-5, .footer-widgets-6 {
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<p class="entry-meta"><time class="entry-time">July 20, 2023</time> By <span class="entry-author"><a href="https://www.drugdeliverybusiness.com/author/sean-whooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span>  </p></header><div class="entry-content"><div class="addtoany_share_save_container addtoany_content addtoany_content_top"><div class="a2a_kit a2a_kit_size_16 addtoany_list" data-a2a-url="https://www.drugdeliverybusiness.com/8-drug-delivery-innovations-to-know/" data-a2a-title="8 drug delivery innovations you should know" style="line-height: 16px;"><a class="a2a_button_facebook" href="/#facebook" title="Facebook" rel="nofollow noopener" target="_blank"><span class="a2a_svg a2a_s__default a2a_s_facebook" style="background-color: rgb(24, 119, 242); width: 16px; line-height: 16px; height: 16px; background-size: 16px; border-radius: 2px;"><svg focusable="false" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"><path fill="#FFF" d="M17.78 27.5V17.008h3.522l.527-4.09h-4.05v-2.61c0-1.182.33-1.99 2.023-1.99h2.166V4.66c-.375-.05-1.66-.16-3.155-.16-3.123 0-5.26 1.905-5.26 5.405v3.016h-3.53v4.09h3.53V27.5h4.223z"></path></svg></span><span class="a2a_label">Facebook</span></a><a class="a2a_button_twitter" href="/#twitter" title="Twitter" rel="nofollow noopener" target="_blank"><span class="a2a_svg a2a_s__default a2a_s_twitter" style="background-color: rgb(29, 155, 240); width: 16px; line-height: 16px; height: 16px; background-size: 16px; border-radius: 2px;"><svg focusable="false" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"><path fill="#FFF" d="M28 8.557a9.913 9.913 0 0 1-2.828.775 4.93 4.93 0 0 0 2.166-2.725 9.738 9.738 0 0 1-3.13 1.194 4.92 4.92 0 0 0-3.593-1.55 4.924 4.924 0 0 0-4.794 6.049c-4.09-.21-7.72-2.17-10.15-5.15a4.942 4.942 0 0 0-.665 2.477c0 1.71.87 3.214 2.19 4.1a4.968 4.968 0 0 1-2.23-.616v.06c0 2.39 1.7 4.38 3.952 4.83-.414.115-.85.174-1.297.174-.318 0-.626-.03-.928-.086a4.935 4.935 0 0 0 4.6 3.42 9.893 9.893 0 0 1-6.114 2.107c-.398 0-.79-.023-1.175-.068a13.953 13.953 0 0 0 7.55 2.213c9.056 0 14.01-7.507 14.01-14.013 0-.213-.005-.426-.015-.637.96-.695 1.795-1.56 2.455-2.55z"></path></svg></span><span class="a2a_label">Twitter</span></a><a class="a2a_button_linkedin" href="/#linkedin" title="LinkedIn" rel="nofollow noopener" target="_blank"><span class="a2a_svg a2a_s__default a2a_s_linkedin" style="background-color: rgb(0, 123, 181); width: 16px; line-height: 16px; height: 16px; background-size: 16px; border-radius: 2px;"><svg focusable="false" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"><path d="M6.227 12.61h4.19v13.48h-4.19V12.61zm2.095-6.7a2.43 2.43 0 0 1 0 4.86c-1.344 0-2.428-1.09-2.428-2.43s1.084-2.43 2.428-2.43m4.72 6.7h4.02v1.84h.058c.56-1.058 1.927-2.176 3.965-2.176 4.238 0 5.02 2.792 5.02 6.42v7.395h-4.183v-6.56c0-1.564-.03-3.574-2.178-3.574-2.18 0-2.514 1.7-2.514 3.46v6.668h-4.187V12.61z" fill="#FFF"></path></svg></span><span class="a2a_label">LinkedIn</span></a><a class="a2a_dd addtoany_share_save addtoany_share" href="https://www.addtoany.com/share#url=https%3A%2F%2Fwww.drugdeliverybusiness.com%2F8-drug-delivery-innovations-to-know%2F&amp;title=8%20drug%20delivery%20innovations%20you%20should%20know"><span class="a2a_svg a2a_s__default a2a_s_a2a" style="background-color: rgb(1, 102, 255); width: 16px; line-height: 16px; height: 16px; background-size: 16px; border-radius: 2px;"><svg focusable="false" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"><g fill="#FFF"><path d="M14 7h4v18h-4z"></path><path d="M7 14h18v4H7z"></path></g></svg></span><span class="a2a_label a2a_localize" data-a2a-localize="inner,Share">Share</span></a></div></div><p><img decoding="async" class="alignright size-medium wp-image-65159" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/8-drug-delivery-innovations-you-need-to-know-2023-300x195.jpg" alt="8 drug delivery innovations you need to know 2023" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/8-drug-delivery-innovations-you-need-to-know-2023-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/8-drug-delivery-innovations-you-need-to-know-2023-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/8-drug-delivery-innovations-you-need-to-know-2023.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195">Innovations in drug delivery never stop, and over the past 12 months or so a wide variety have been in the spotlight.</p>
<p>Constant progress continues in the diabetes space, both in the form of insulin delivery and other drug delivery methods. Elsewhere, we see implants, patches, syringes and more showcasing the many ways we can deliver therapeutics.</p>
<p>About a year ago, we clued in readers to a <a href="https://www.drugdeliverybusiness.com/6-drug-delivery-innovations-you-need-to-know/" target="_blank" rel="noopener">list of six drug delivery innovations they should know</a>. Here, we provide a couple of updates on those and try to introduce a few more developments that you should know:</p>
<h3>The latest in automated insulin delivery tech</h3>
<p>Automated insulin delivery represents one of the most high-profile markets in drug delivery, with the technology providing potentially life-saving therapy for people with diabetes.</p>
<p></p><figure id="attachment_65136" aria-describedby="caption-attachment-65136" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-65136" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/Tandem-Mobi-Insulin-Pump-with-App-300x195.jpg" alt="Tandem Mobi Insulin Pump with App" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/Tandem-Mobi-Insulin-Pump-with-App-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/Tandem-Mobi-Insulin-Pump-with-App-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/07/Tandem-Mobi-Insulin-Pump-with-App.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-65136" class="wp-caption-text">The Mobi automated insulin pump with the accompanying mobile app [Image courtesy of Tandem Diabetes Care]</figcaption></figure>Last year’s roundup included the <a href="https://www.drugdeliverybusiness.com/fda-clears-insulets-next-generation-omnipod-5-wearable-insulin-pump-patch/" target="_blank" rel="noopener">FDA-cleared Omnipod 5</a> automated insulin delivery system from Insulet. At the time, the Medtronic MiniMed 780G had not yet been cleared, <a href="https://www.drugdeliverybusiness.com/fda-approves-minimed-780g-insulin-pump-medtronic/" target="_blank" rel="noopener">although that changed in April</a>.<p></p>
<p>There’s still plenty of innovation going on in this market, and a few more automated insulin delivery systems made waves since.</p>
<p>Earlier this month, <a href="https://www.drugdeliverybusiness.com/fda-clears-tandem-mobi-automated-insulin-pump/" target="_blank" rel="noopener">Tandem Diabetes Care won FDA clearance for its new Tandem Mobi</a> automated insulin delivery system. Tandem says Mobi, which is fully controllable from a mobile app, is the world’s smallest durable AID system. It features a 200-unit insulin cartridge and an on-pump button to provide an alternative to phone control for insulin boluses. It comes in at less than half the size of the existing Tandem pump system, the&nbsp;<a href="https://www.drugdeliverybusiness.com/tandem-reports-positive-research-for-its-artificial-pancreas-tech/" target="_blank" rel="noopener">t:slim X2 pump</a>.</p>
<p>In May, the <a href="https://www.drugdeliverybusiness.com/fda-clears-automated-insulin-pump-beta-bionics/" target="_blank" rel="noopener">FDA cleared the Beta Bionics iLet ACE automated insulin pump and iLet dosing decision software</a>. Beta Bionics’ iLet Bionic Pancreas uses an adaptive, closed-loop algorithm. It initializes with the user’s body weight and requires no additional insulin dosing parameters. The algorithm removes the need to manually adjust insulin pump therapy settings and variables.</p>
<p>While Omnipod 5 marked Insulet’s progress in automated insulin delivery last year, the company is already picking up steam with another offering. In April, the <a href="https://www.drugdeliverybusiness.com/fda-clears-basal-insulin-pod-insulet-diabetes/" target="_blank" rel="noopener">FDA cleared Omnipod GO</a> — a long-acting insulin delivery system for the basal-only insulin population.</p>
<p>Keep an eye out for <a href="https://www.drugdeliverybusiness.com/tidepool-loop-automated-insulin-delivery-fda-clearance/" target="_blank" rel="noopener">Tidepool Loop</a> (partnered with BD diabetes spinoff Embecta) and <a href="https://www.drugdeliverybusiness.com/ypsomed-camdiab-insulin-dosing-abbott-freestyle-libre-3/" target="_blank" rel="noopener">Ypsomed</a> (partnered with Abbott and Dexcom CGMs).</p>
<h3>Insulin pen add-ons</h3>
<p></p><figure id="attachment_64793" aria-describedby="caption-attachment-64793" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="wp-image-64793 size-medium" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/02/Innovation-Zed-InsulCheck-Dose-300x195.jpg" alt="Innovation Zed InsulCheck Dose" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/02/Innovation-Zed-InsulCheck-Dose-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/02/Innovation-Zed-InsulCheck-Dose-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/02/Innovation-Zed-InsulCheck-Dose.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-64793" class="wp-caption-text">The InsulCheck Dose device. [Image courtesy of Innovation Zed]</figcaption></figure>For those who don’t use automated insulin pumps and want to treat their diabetes in other ways, plenty of other innovations came to the fore recently.<p></p>
<p>Insulin injector pens are one big piece of the market, and two recent innovations improving them are worth touching on.</p>
<p>In December 20222, <a href="https://www.drugdeliverybusiness.com/fda-clears-mallya-smart-insulin-pen-device-biocorp/" target="_blank" rel="noopener">Biocorp won FDA 510(k) clearance for its Mallya device</a> that connects insulin pens. The Mallya smart sensor attaches directly to insulin pen injectors to make them connected devices. It automatically collects and records key treatment information and transmits it to a dedicated digital application. That data includes selected insulin units, date and time of injection.</p>
<p>Innovation Zed makes a similar device,<a href="https://www.drugdeliverybusiness.com/innovation-zed-wins-ce-mark-for-insulin-pen-add-on-device/" target="_blank" rel="noopener"> receiving CE mark approval in February</a> for InsulCheck Dose. The company designed InsulCheck Dose as a single-unit add-on device for pen injectors. It automatically captures dose value dialed, injection event time stamps and temperature. The device also captures mounting and unmounting events.</p>
<h3>Alternative diabetes therapies utilizing drug delivery methods</h3>
<p>Aside from insulin delivery, companies are developing innovative alternatives to manage and treat diabetes.</p>
<p><a href="https://www.drugdeliverybusiness.com/vivani-medical-subdermal-drug-delivery-implant-diabetes/" target="_blank" rel="noopener">Vivani Medical’s NanoPortal technology</a> is an implant for steady medication delivery over extended periods of time. The company aims to guarantee correct doses for patients while mitigating safety concerns around fluctuating drug release profiles. The technology can also deliver large hydrophilic molecules, including peptides and proteins. The company believes this enables a broader range of therapeutic applications.</p>
<figure id="attachment_64818" aria-describedby="caption-attachment-64818" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-64818" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/03/Vivani-Nano-Portal-300x195.jpg" alt="Vivani NanoPortal diabetes implant" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/03/Vivani-Nano-Portal-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/03/Vivani-Nano-Portal-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/03/Vivani-Nano-Portal.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-64818" class="wp-caption-text">Vivani’s NanoPortal technology [Image courtesy of Vivani]</figcaption></figure>
<p class="p1">Vivani’s targeted conditions for this technology include type 2 diabetes, non-alcoholic steatohepatitis (NASH) and obesity.</p>
<p>Sernova has been making progress on its Cell Pouch System, an implantable and scalable medical device that forms a natural environment in the body for the long-term survival and function of therapeutic cells. Those cells release necessary proteins or factors missing from the body to treat chronic diseases, including insulin-dependent diabetes.</p>
<p>Keep your eyes out for a <a href="https://www.drugdeliverybusiness.com/humacyte-jdrf-biovascular-pancreas-diabetes/" target="_blank" rel="noopener">collaboration between Humacyte and JDRF,</a> which are developing a biovascular pancreas (BVP).</p>
<p>They aim to advance the development of Humacyte’s BVP for treating type 1 diabetes. Humacyte designed its BVP to deliver insulin-producing islets using its investigational, tissue-engineered blood vessel. The company calls it the Human Acellular Vessel (HAV).</p>
<h3>Ear tubes with liquid-infused materials for treating ear infections</h3>
<p><a href="https://www.drugdeliverybusiness.com/ear-tubes-liquid-infused-materials-infection/" target="_blank" rel="noopener">A research collaboration found a potential drug delivery innovation to improve outcomes for ear tubes</a> known as tympanostomy tubes (TTs). This research came out of the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Massachusetts Eye and Ear (MEE) in Boston.</p>
<p>Using TTs fabricated from a liquid-infused material — called&nbsp;<em>i</em>TTs — researchers co-optimized difficult-to-reconcile functions. These include fast drug delivery into the middle ear and fast drainage out, resistance against water crossing from the outside into the middle ear, and preventing bacterial and cell adhesion to tubes.</p>
<p>The researchers used chinchillas for an in vivo model relevant to the human ear to compare the <em>i</em>TTs’ performance against traditional TTs. Chinchillas are the gold standard for studying middle ear diseases and treatments, the team said, because chinchillas and humans have a similar frequency range of hearing and similarly sized tympanic membranes.</p>
<p>The <em>I</em>TTs preserved hearing and enabled easy and reliable dosing of antibiotic ear drops to the middle ear compared to conventional tubes, the researchers said.</p>
<h3>Micron Biomedical’s needle-free drug delivery tech</h3>
<p></p><figure id="attachment_65003" aria-describedby="caption-attachment-65003" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-65003" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/Micron-Biomedical_waifu2x_photo_noise1_scale_waifu2x_photo_noise1_scale-300x195.jpg" alt="Micron Biomedical dissovable needle-free drug delivery patch" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/Micron-Biomedical_waifu2x_photo_noise1_scale_waifu2x_photo_noise1_scale-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/Micron-Biomedical_waifu2x_photo_noise1_scale_waifu2x_photo_noise1_scale-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/Micron-Biomedical_waifu2x_photo_noise1_scale_waifu2x_photo_noise1_scale.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-65003" class="wp-caption-text">[Image from Micron Biomedical website]</figcaption></figure>Atlanta-based Micron Biomedical develops dissolvable, microarray-based products to simplify drug delivery and vaccines.<p></p>
<p>The patented microarray technology enables the administration of drugs and vaccines that require cold storage and administration within minutes.&nbsp; It can be self-administered or caregiver-administered.</p>
<p>Micron says its technology simplifies transport, storage and administration while eliminating traditional injection sharps waste. Completed trials demonstrated clinical efficacy and strong patient preference, according to the company.</p>
<p>In May, <a href="https://www.drugdeliverybusiness.com/micron-biomedical-17m-needle-free-drug-delivery/" target="_blank" rel="noopener">Micron announced that it added $3 million to its Series A fundraising round</a>, bringing the round’s total to $17 million.</p>
<h3>MIT’s transdermal drug delivery patch</h3>
<p>Researchers at MIT <a href="https://www.drugdeliverybusiness.com/researchers-wearable-patch-drug-delivery-skin/" target="_blank" rel="noopener">potentially found a way to address the difficulties of transdermal drug delivery through a new wearable patch</a>.</p>
<p></p><figure id="attachment_64956" aria-describedby="caption-attachment-64956" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-64956" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/04/MIT-Ultrasound-Patch-for-drug-delivery-300x195.jpg" alt="MIT Ultrasound Patch for drug delivery" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/04/MIT-Ultrasound-Patch-for-drug-delivery-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/04/MIT-Ultrasound-Patch-for-drug-delivery-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/04/MIT-Ultrasound-Patch-for-drug-delivery.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-64956" class="wp-caption-text">The ultrasound patch developed by MIT researchers for targeted drug delivery [Image courtesy of MIT]</figcaption></figure>The team thinks the skin can enable drugs to travel directly to where they’re needed. That offers benefits in wound care, pain relief and more. But the outer layer of the skin is a tough barrier that prevents most small molecules from passing through.<p></p>
<p>To address this, the researchers developed a wearable patch that applies painless, ultrasonic waves to the skin. This creates tiny channels that drugs can pass through, potentially enabling treatments for skin conditions. The researchers believe they can adapt the technology to deliver hormones, muscle relaxants and other drugs.</p>
<p>Their patch design features several disc-shaped piezoelectric transducers that convert electric currents into mechanical energy. Each disc is embedded in a polymeric cavity that contains drug molecules dissolved in a liquid solution. When the current is applied to the piezoelectric elements, it generates pressure waves in the fluid. That, in turn, makes bubbles that burst against the skin, producing microjets of fluid that can penetrate the skin’s outer layer.</p>
<p>The MIT team says the latest version of their device enables drugs to penetrate a few millimeters into the skin. This makes the approach useful for drugs that act locally within the skin. Those include niacinamide or vitamin C for treating age spots or other dark spots, and topical drugs used to heal burns.</p>
<h3>Pre-filled syringes</h3>
<p>While many of these drug delivery offerings represent potential new avenues, the well-known pre-filled syringe continues to evolve.</p>
<p></p><figure id="attachment_65031" aria-describedby="caption-attachment-65031" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-65031" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/BD-PosiFlush-SafeScrub-Syringe-300x195.jpg" alt="BD PosiFlush SafeScrub Syringe" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/BD-PosiFlush-SafeScrub-Syringe-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/BD-PosiFlush-SafeScrub-Syringe-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/05/BD-PosiFlush-SafeScrub-Syringe.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-65031" class="wp-caption-text">The PosiFlush SafeScrub syringe [Image courtesy of BD]</figcaption></figure>BD received clearance for its <a href="https://www.drugdeliverybusiness.com/bd-expands-availability-flush-pre-filled-syringe/" target="_blank" rel="noopener">PosiFlush SafeScrub pre-filled syringe</a> and introduced it to select customers in October 2022. The PosiFlush SafeScrub syringe has an integrated disinfection unit to reinforce compliance with infection prevention guidelines and simplify nursing workflow.<p></p>
<p>BD built the disinfection unit into the tip cap of the&nbsp; syringe. In vitro testing demonstrated a significant reduction in microbial growth associated with catheter-related bloodstream infections (CRBSIs).</p>
<p>Earlier this year, Schott Pharma <a href="https://www.drugdeliverybusiness.com/schott-pharma-pre-filled-polymer-syringes/" target="_blank" rel="noopener">launched its Toppac Freeze pre-fillable syringes for delivering deep-cold drugs</a>. Deep-cold drugs are stored and transported on dry ice at temperatures reaching -100°C.</p>
<p>Schott designed the syringes using an advanced, pharmaceutical-grade polymer, delivered in a standardized nest-and-tub configuration. This ensures compatibility on major fill-finish lines to simplify the filling process.</p>
<p>Schott used cyclic olefin copolymer (COC), a break-resistant, biologically inert material that has advanced barrier properties to ensure drug stability. Its scientific data package features data on container closure integrity, functionality and particulate generation after freeze and thaw cycles.</p>
<h3>Stevanato Group’s on-body drug delivery system</h3>
<p>In March, Stevanato Group announced plans to&nbsp;<a href="https://www.drugdeliverybusiness.com/stevanato-group-thermo-fisher-on-body-drug-delivery/" target="_blank" rel="noopener">bring an on-body drug delivery device to market through a collaboration with Thermo Fisher Scientific</a>. The companies intend to offer the platform as an integrated device and fill-and-finish solution.</p>
<p></p><figure id="attachment_65064" aria-describedby="caption-attachment-65064" style="width: 300px" class="wp-caption alignright"><img decoding="async" loading="lazy" class="size-medium wp-image-65064" src="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/06/Stevanato-Group-Vertiva-on-body-drug-delivery-system-300x195.jpg" alt="Stevanato Group Vertiva on-body drug delivery system" srcset="https://www.drugdeliverybusiness.com/wp-content/uploads/2023/06/Stevanato-Group-Vertiva-on-body-drug-delivery-system-300x195.jpg 300w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/06/Stevanato-Group-Vertiva-on-body-drug-delivery-system-768x499.jpg 768w, https://www.drugdeliverybusiness.com/wp-content/uploads/2023/06/Stevanato-Group-Vertiva-on-body-drug-delivery-system.jpg 770w" sizes="(max-width: 300px) 100vw, 300px" width="300" height="195"><figcaption id="caption-attachment-65064" class="wp-caption-text">The Vertiva on-body delivery system [Image courtesy of Stevanato Group]</figcaption></figure>Stevanato <a href="https://www.drugdeliverybusiness.com/stevanato-group-unveils-drug-delivery-device/">unveiled the device last month</a>, calling the patented, on-body drug delivery system “Vertiva.”<p></p>
<p>Stevanato Group designed Vertiva with the ability to switch between basal and bolus injections and said it is suitable for a wide range of subcutaneous therapies. The system’s single-use pod has a pre-filled, pre-loaded 3mL ISO cartridge. It also comes with a multi-use controller for potential sustainability and affordability benefits. Both parts communicate through a patented, magnetically coupled drive mechanism.</p>
<p>Stevanato Group said its device can adapt to different delivery profiles and enable the administration of small-molecule drugs and biologics. The company has the design under development to cover a broad range of volumes up to 10mL.</p>
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t={year:"years",years:"years",quarter:"quarters",quarters:"quarters",month:"months",months:"months",week:"weeks",weeks:"weeks",day:"days",days:"days",hour:"hours",hours:"hours",minute:"minutes",minutes:"minutes",second:"seconds",seconds:"seconds",millisecond:"milliseconds",milliseconds:"milliseconds"}[e?e.toLowerCase():e];if(!t)throw new Cn(e);return t},e.isDuration=function(e){return e&&e.isLuxonDuration||!1};var t=e.prototype;return t.toFormat=function(e,t){void 0===t&&(t={});var n=gn({},t,{floor:!1!==t.round&&!1!==t.floor});return this.isValid?Ur.create(this.loc,n).formatDurationFromString(this,e):"Invalid Duration"},t.toHuman=function(e){var t=this;void 0===e&&(e={});var n=ho.map((function(n){var r=t.values[n];return ir(r)?null:t.loc.numberFormatter(gn({style:"unit",unitDisplay:"long"},e,{unit:n.slice(0,-1)})).format(r)})).filter((function(e){return e}));return this.loc.listFormatter(gn({type:"conjunction",style:e.listStyle||"narrow"},e)).format(n)},t.toObject=function(){return 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n=this.shiftTo("hours","minutes","seconds","milliseconds"),r="basic"===e.format?"hhmm":"hh:mm";e.suppressSeconds&&0===n.seconds&&0===n.milliseconds||(r+="basic"===e.format?"ss":":ss",e.suppressMilliseconds&&0===n.milliseconds||(r+=".SSS"));var i=n.toFormat(r);return e.includePrefix&&(i="T"+i),i},t.toJSON=function(){return this.toISO()},t.toString=function(){return this.toISO()},t.toMillis=function(){return this.as("milliseconds")},t.valueOf=function(){return this.toMillis()},t.plus=function(t){if(!this.isValid)return this;for(var n,r=e.fromDurationLike(t),i={},o=Dn(ho);!(n=o()).done;){var s=n.value;(lr(r.values,s)||lr(this.values,s))&&(i[s]=r.get(s)+this.get(s))}return yo(this,{values:i},!0)},t.minus=function(t){if(!this.isValid)return this;var n=e.fromDurationLike(t);return this.plus(n.negate())},t.mapUnits=function(e){if(!this.isValid)return this;for(var t={},n=0,r=Object.keys(this.values);n<r.length;n++){var i=r[n];t[i]=Tr(e(this.values[i],i))}return 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this.isValid?this.values.years||0:NaN}},{key:"quarters",get:function(){return this.isValid?this.values.quarters||0:NaN}},{key:"months",get:function(){return this.isValid?this.values.months||0:NaN}},{key:"weeks",get:function(){return this.isValid?this.values.weeks||0:NaN}},{key:"days",get:function(){return this.isValid?this.values.days||0:NaN}},{key:"hours",get:function(){return this.isValid?this.values.hours||0:NaN}},{key:"minutes",get:function(){return this.isValid?this.values.minutes||0:NaN}},{key:"seconds",get:function(){return this.isValid?this.values.seconds||0:NaN}},{key:"milliseconds",get:function(){return this.isValid?this.values.milliseconds||0:NaN}},{key:"isValid",get:function(){return null===this.invalid}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}();var go=function(){function e(e){this.s=e.start,this.e=e.end,this.invalid=e.invalid||null,this.isLuxonInterval=!0}e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Interval is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new _n(r);return new e({invalid:r})},e.fromDateTimes=function(t,n){var r=gs(t),i=gs(n),o=function(e,t){return e&&e.isValid?t&&t.isValid?t<e?go.invalid("end before start","The end of an interval must be after its start, but you had start="+e.toISO()+" and end="+t.toISO()):null:go.invalid("missing or invalid end"):go.invalid("missing or invalid start")}(r,i);return null==o?new e({start:r,end:i}):o},e.after=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i,i.plus(r))},e.before=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i.minus(r),i)},e.fromISO=function(t,n){var r=(t||"").split("/",2),i=r[0],o=r[1];if(i&&o){var 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n=(void 0===t?{}:t).separator,r=void 0===n?" – ":n;return this.isValid?""+this.s.toFormat(e)+r+this.e.toFormat(e):"Invalid Interval"},t.toDuration=function(e,t){return this.isValid?this.e.diff(this.s,e,t):po.invalid(this.invalidReason)},t.mapEndpoints=function(t){return e.fromDateTimes(t(this.s),t(this.e))},pn(e,[{key:"start",get:function(){return this.isValid?this.s:null}},{key:"end",get:function(){return this.isValid?this.e:null}},{key:"isValid",get:function(){return null===this.invalidReason}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}(),wo=function(){function e(){}return e.hasDST=function(e){void 0===e&&(e=li.defaultZone);var t=ps.now().setZone(e).set({month:12});return!e.isUniversal&&t.offset!==t.set({month:6}).offset},e.isValidIANAZone=function(e){return Kr.isValidZone(e)},e.normalizeZone=function(e){return 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xo={arab:"[٠-٩]",arabext:"[۰-۹]",bali:"[᭐-᭙]",beng:"[০-৯]",deva:"[०-९]",fullwide:"[0-9]",gujr:"[૦-૯]",hanidec:"[〇|一|二|三|四|五|六|七|八|九]",khmr:"[០-៩]",knda:"[೦-೯]",laoo:"[໐-໙]",limb:"[᥆-᥏]",mlym:"[൦-൯]",mong:"[᠐-᠙]",mymr:"[၀-၉]",orya:"[୦-୯]",tamldec:"[௦-௯]",telu:"[౦-౯]",thai:"[๐-๙]",tibt:"[༠-༩]",latn:"\\d"},So={arab:[1632,1641],arabext:[1776,1785],bali:[6992,7001],beng:[2534,2543],deva:[2406,2415],fullwide:[65296,65303],gujr:[2790,2799],khmr:[6112,6121],knda:[3302,3311],laoo:[3792,3801],limb:[6470,6479],mlym:[3430,3439],mong:[6160,6169],mymr:[4160,4169],orya:[2918,2927],tamldec:[3046,3055],telu:[3174,3183],thai:[3664,3673],tibt:[3872,3881]},To=xo.hanidec.replace(/[\[|\]]/g,"").split("");function Mo(e,t){var n=e.numberingSystem;return void 0===t&&(t=""),new RegExp(""+xo[n||"latn"]+t)}function Oo(e,t){return void 0===t&&(t=function(e){return e}),{regex:e,deser:function(e){var n=e[0];return t(function(e){var t=parseInt(e,10);if(isNaN(t)){t="";for(var n=0;n<e.length;n++){var 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zo=null;function Ao(e,t){if(e.literal)return e;var n=Ur.macroTokenToFormatOpts(e.val);if(!n)return e;var r=Ur.create(t,n).formatDateTimeParts((zo||(zo=ps.fromMillis(1555555555555)),zo)).map((function(e){return function(e,t,n){var r=e.type,i=e.value;if("literal"===r)return{literal:!0,val:i};var o=n[r],s=Fo[r];return"object"==typeof s&&(s=s[o]),s?{literal:!1,val:s}:void 0}(e,0,n)}));return r.includes(void 0)?e:r}function Lo(e,t,n){var r=function(e,t){var n;return(n=Array.prototype).concat.apply(n,e.map((function(e){return Ao(e,t)})))}(Ur.parseFormat(n),e),i=r.map((function(t){return n=t,i=Mo(r=e),o=Mo(r,"{2}"),s=Mo(r,"{3}"),u=Mo(r,"{4}"),a=Mo(r,"{6}"),l=Mo(r,"{1,2}"),c=Mo(r,"{1,3}"),f=Mo(r,"{1,6}"),d=Mo(r,"{1,9}"),h=Mo(r,"{2,4}"),m=Mo(r,"{4,6}"),y=function(e){return{regex:RegExp((t=e.val,t.replace(/[\-\[\]{}()*+?.,\\\^$|#\s]/g,"\\$&"))),deser:function(e){return e[0]},literal:!0};var t},v=function(e){if(n.literal)return y(e);switch(e.val){case"G":return 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t={},n=po.normalizeUnit(e);switch(n){case"years":t.month=1;case"quarters":case"months":t.day=1;case"weeks":case"days":t.hour=0;case"hours":t.minute=0;case"minutes":t.second=0;case"seconds":t.millisecond=0}if("weeks"===n&&(t.weekday=1),"quarters"===n){var r=Math.ceil(this.month/3);t.month=3*(r-1)+1}return this.set(t)},t.endOf=function(e){var t;return this.isValid?this.plus((t={},t[e]=1,t)).startOf(e).minus(1):this},t.toFormat=function(e,t){return void 0===t&&(t={}),this.isValid?Ur.create(this.loc.redefaultToEN(t)).formatDateTimeFromString(this,e):"Invalid DateTime"},t.toLocaleString=function(e,t){return void 0===e&&(e=An),void 0===t&&(t={}),this.isValid?Ur.create(this.loc.clone(t),e).formatDateTime(this):"Invalid DateTime"},t.toLocaleParts=function(e){return void 0===e&&(e={}),this.isValid?Ur.create(this.loc.clone(e),e).formatDateTimeParts(this):[]},t.toISO=function(e){var t=void 0===e?{}:e,n=t.format,r=void 0===n?"extended":n,i=t.suppressSeconds,o=void 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